b＞Objectives:/b＞ Kawasaki disease (KD) is a leading cause of acquired heart diseases in developed countries. Around 10-15% of cases with KD are refractory to intravenous immunoglobulin therapy (IVIG). Since the incidence of refractory KD is increasing, this study was to investigate the predicting factors of refractory KD for intensive primary therapy. b＞Methods and Materials:/b＞ We reviewed retrospectively the clinical data of patients with KD admitted at the Wonju Christian Hospital from January 2005 to December 2008. Patients with typical KD were included in this study. The differences of laboratory and demographic parameters between IVIG respond group and IVIG non respond group were analyzed. 13 patients with urinary tract infection were collected randomly as febrile control group. b＞Results: /b＞ Among 77 patients diagnosed as complete KD, 13 patients (16.9% of total patient with complete KD) were IVIG non respond group. Fever duration and hospital day were significantly longer in IVIG non respond group than IVIG respond group ( P 0.01). And serum levels of albumin and sodium were lower significantly in IVIG non respond group ( P 0.05). Kobayashi score was statistically significant in differentiating two groups in our study ( P = 0.015). High percentage of the neutrophils and low percentage of lymphocytes were observed significantly during the subacute phase in IVIG non respond group ( P 0.05). Twelve patients had coronary arterial dilatations in acute phase, there was no significant difference between two groups in chronic coronary complications. b＞Conclusions: /b＞ Knowing the risk factors of refractory KD make the physicians enable to do timely management and lead to better prognosis. This study demonstrated that the known risk factors of refractory KD are valuable in predicting IVIG non respond group in Korean patients with KD in a single referral center.